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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Serious Infection Risk with Systemic Treatments for Psoriasis: A Systematic Review and Network Meta-analysis
Heber Rew Bright Bright1, Duc Binh Phan1, Amna Zahid1
1Dermatology Centre, Northern Care Alliance NHS Foundation Trust and Division of Musculoskeletal and Dermatological Sciences, Manchester NIHR Biomedical Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Dermatology and Therapy
|October 31, 2025
Summary
Systemic psoriasis treatments like infliximab and adalimumab may increase serious infection risk. This risk was higher compared to other drugs in a network meta-analysis of psoriasis therapies.
Area of Science:
- Dermatology
- Pharmacology
- Infectious Diseases
Background:
- Systemic treatments for psoriasis carry a risk of serious infections.
- Assessing this risk is crucial for patient safety.
Purpose of the Study:
- To evaluate the risk of serious infections associated with systemic psoriasis treatments.
- To compare infection risks across different systemic psoriasis therapies.
Main Methods:
- A systematic review and frequentist network meta-analysis (NMA) of randomized controlled trials (RCTs) and non-randomized studies of interventions (NRSIs) were conducted.
- Studies published until September 2024, involving at least 50 patients with plaque psoriasis, were included.
- Serious infection was defined as an event requiring hospitalization, intravenous antibiotics, or resulting in death.
Main Results:
- The RCT network found no increased serious infection risk among different systemic treatments.
- The NRSI network indicated higher risks with infliximab and adalimumab compared to other drugs.
- In the combined NMA, infliximab and adalimumab showed significantly higher serious infection risks than acitretin, bimekizumab, methotrexate, placebo, risankizumab, and secukinumab.
Conclusions:
- Tumor necrosis factor alpha (TNFα) inhibitors, specifically adalimumab and infliximab, are associated with an increased risk of serious infections.
- These findings can help clinicians and patients make informed decisions regarding psoriasis treatment and infection risk.
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