Blood urea nitrogen to serum albumin ratio predicts 28-day and 90-day mortality in patients with acute pancreatitis: A retrospective cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.The ratio of blood urea nitrogen to albumin (BAR) is a strong predictor of mortality in acute pancreatitis. Higher BAR levels indicate a greater risk of death within 28 and 90 days for these patients.
Area Of Science
- Gastroenterology
- Critical Care Medicine
- Biomarker Research
Background
- Acute pancreatitis is a severe condition with high mortality rates.
- Early identification of high-risk patients is crucial for improving outcomes.
- The ratio of blood urea nitrogen to albumin (BAR) is a potential prognostic marker.
Purpose Of The Study
- To investigate the association between BAR and 28-day and 90-day mortality in acute pancreatitis patients.
- To evaluate BAR as a prognostic predictor for mortality in acute pancreatitis.
Main Methods
- Retrospective cohort study using the MIMIC-IV database.
- Calculation of BAR from initial blood urea nitrogen and serum albumin.
- Kaplan-Meier analysis, restricted cubic spline curves, and multivariate Cox regression to assess mortality risk.
Main Results
- Elevated BAR levels were significantly associated with increased 28-day and 90-day mortality (Log-rank P < 0.001).
- A linear, positive relationship was observed between BAR and mortality.
- BAR demonstrated strong predictive value (AUC 0.802 for 28-day, 0.798 for 90-day mortality), comparable to SAPS II.
Conclusions
- Higher BAR values are significantly linked to increased mortality in acute pancreatitis.
- BAR is a simple, effective tool for identifying patients at higher risk of death.
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