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Updated: Jan 6, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Energy status orchestrates YTHDF1 phase separation and tumorigenesis

Haisheng Yu1, Jie Shi1, Rongrong He2

  • 1Department of Radiation and Medical Oncology, State Key Laboratory of Metabolism and Regulation in Complex Organisms, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Hubei Key Laboratory of Tumor Biological Behavior, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China; Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430071, China.

Cell Reports
|October 31, 2025
PubMed
Summary

Cellular energy status influences cancer via adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling. Targeting YTHDF1 modifications with AMPK agonists or ketogenic diets inhibits tumor growth, offering new cancer treatment strategies.

Keywords:
AMPKCP: MetabolismO-GlcNAcylationOGTYTHDF1breast cancerenergy statusketogenic dietphase separationphosphorylationprotein synthesis

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