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Pan-immune inflammation value: A novel biomarker for cataract
Chuan-Xi Wang1, Jia-Wei Fan1, Jing-Hui Liu1,2
1Department of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Plos One
|October 31, 2025
Summary
Higher Pan-immune inflammation value (PIV) is linked to increased cataract prevalence. This finding emphasizes the role of systemic inflammation markers in cataract development and clinical detection.
Area of Science:
- Ophthalmology
- Immunology
- Public Health
Background:
- Inflammation is a key factor in cataract formation.
- Pan-immune inflammation value (PIV) is an emerging marker for systemic inflammation.
- The relationship between PIV and cataract development requires further investigation.
Purpose of the Study:
- To investigate the association between Pan-immune inflammation value (PIV) and cataract prevalence.
- To determine if PIV can serve as a predictive marker for cataract formation.
Main Methods:
- Analysis of 8,235 participants from the National Health and Nutrition Examination Survey (NHANES) (2005-2008).
- Log-transformation of PIV and application of weighted logistic regression.
- Utilized restricted cubic splines (RCS), subgroup, sensitivity analyses, and ROC curves to assess associations and predictive performance.
Main Results:
- Cataract prevalence was 6.6% in the study cohort.
- A positive linear association was observed between higher ln-PIV and cataract prevalence (OR=1.35, P=0.015).
- PIV demonstrated superior predictive ability for cataract compared to other inflammatory indices.
Conclusions:
- Elevated PIV levels are significantly associated with increased cataract prevalence.
- Inflammatory markers like PIV hold potential value in assessing cataract development.
- Findings suggest PIV could offer new insights for clinical cataract detection strategies.
