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Updated: Jan 12, 2026

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The mechanical response of vinculin

Xuyao Liu1,2, Jingzhun Liu1,2, Yinan Wang1,2

  • 1Department of Physics, National University of Singapore, Singapore 117542, Singapore.

Science Advances
|October 31, 2025
PubMed
Summary

Vinculin acts as a molecular switch, dynamically unfolding and refolding under force. This mechanosensitive behavior allows vinculin to directly regulate protein interactions at cell adhesions.

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