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Updated: Jan 12, 2026
Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
Published on: January 5, 2024
Effectiveness of Electroacupuncture Combined with Pregabalin in the Treatment of Trigeminal Herpetic Neuralgia: A
Shimin Li1, Xilong Yang2, Yunfan Xia2
1Hangzhou Third People's Hospital, Hangzhou, China.
Background:
Trigeminal herpetic neuralgia, a common type of Zoster-associated pain (ZAP), affects individuals across all ages groups and poses a significant societal burden all over the world. Electroacupuncture (EA) is increasingly used in the treatment of ZAP due to its affordability, high safety profile, absence of adverse reactions, and high patient acceptance. Consequently, it is essential to conduct randomized controlled trials to evaluate the effectiveness and safety of EA in treating ZAP and to determine if EA can be used as an alternative to pregabalin.
Patients And Methods:
A total of 102 patients with trigeminal herpetic neuralgia will be enrolled from 2 hospitals and randomly assigned to the EA group, pregabalin group, or EA + pregabalin group in a 1:1:1 ratio using a simple random number table. The study will consist of a 4-week treatment period followed by a 4-week follow-up period. The primary outcome measure will be pain intensity, while secondary outcomes will include mood state, sleep quality, and quality of life. Adverse reactions will be thoroughly evaluated.
Conclusion:
This study aims to elucidate the clinical effectiveness of EA combined with pregabalin for trigeminal herpetic neuralgia and to objectively compare the effectiveness and safety of EA versus oral pregabalin in the treatment of trigeminal herpetic neuralgia.
