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Updated: Jan 6, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Synthesis of Sandwich-α-Diimine Ligands via Copper-Mediated Stille Coupling
Girish G Ramachandru1, Olafs Daugulis1
1Department of Chemistry, University of Houston, Houston, Texas 77204-5003, United States.
Abstract:
While sandwich diimines have found use in transition metal catalysis, the general method for their preparation has been lacking. This approach utilizes a copper-mediated Stille-type coupling between aryl stannanes and α-diimines bearing 8-bromonaphthylimino group in commercial-grade N,N-dimethylformamide solvent and employs CuI or thiophene-2-carboxylate to promote the reactions. No other additives or bases are required. Electron-poor, electron-rich, heterocyclic, and hindered aryl stannanes can be employed as coupling reagents. Ligand scaffolds derived from structurally diverse α-diketones can be used.
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