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Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research
Published on: September 27, 2024
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Bioactive glasses as bone substitutes for animal critical defects: A systematic review
Luiza Bastos Nozari1, Hiskell Francine Fernandes E Oliveira2, Gabriela Dandaro Marinho2
1Department of Prothesis, Oral and Maxillofacial Surgery and Traumatology. School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.
Brazilian Dental Journal
|October 31, 2025
Summary
Bioactive glasses (BGs) show promise for bone repair in animal models, enhancing bone formation in critical defects. However, study variations limit definitive conclusions, highlighting the need for standardized methods in bone regeneration research.
Area of Science:
- Biomaterials Science
- Orthopedic Research
- Regenerative Medicine
Background:
- Bioactive glasses (BGs) are known for bone bonding and osteoconductive properties.
- Previous studies on BGs for bone repair show inconsistent results, with no ideal formulation for critical defects.
- A systematic review is needed to analyze evidence on BG-based biomaterials for bone regeneration.
Purpose of the Study:
- To systematically review and analyze evidence on BG-based biomaterials for bone regeneration in animal models with critical defects.
- To assess the efficacy of BG-based biomaterials in promoting bone formation.
- To identify limitations and areas for improvement in current research.
Main Methods:
- Systematic literature review following PRISMA guidelines, registered in PROSPERO.
- Searched PubMed, Web of Science, and Scopus databases.
- Included 9 studies out of 1,467 identified; assessed risk of bias using SYRCLE RoB Tool.
Main Results:
- Most included studies in rats and rabbits showed improved bone formation with BG-based biomaterials compared to controls.
- Key parameters indicating improvement included bone volume, bone mineral density, and trabecular bone characteristics.
- Significant study heterogeneity was observed, preventing definitive conclusions.
Conclusions:
- BG-based biomaterials demonstrate potential for enhancing bone formation in critical-sized defects.
- Study heterogeneity and lack of standardized assessment methods hinder reliable efficacy evaluation.
- Standardized methods are crucial for robust evidence generation and improved clinical translation in bone regeneration.
