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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
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Dynamics of anterior pituitary function in the acute phase of traumatic brain injury: a prospective cohort

Eder Cáceres1,2, Juan Olivella-Gómez3, André Emilio Viñán Garcés3

  • 1Unisabana Center for Translational Science, School of Medicine, Universidad de La Sabana - Chía, Colombia.

Critical Care Science
|October 31, 2025
PubMed
Abstract

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Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
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Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...