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Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening
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In silico evaluation of cardiac tissue-engineered patch interventions.

John Patrick Sayut Jr1, Javiera Jilberto1, Mia Bonini1

  • 1Department of Biomedical Engineering, University of Michigan, 1221 Beal Avenue, Ann Arbor, MI, 48109-2102, USA.

Computers in Biology and Medicine
|October 31, 2025
PubMed
Summary
This summary is machine-generated.

Engineered cardiac tissue patches can improve heart function in severe heart failure. Transmural patches with aligned fibers and active stress generation significantly boost stroke volume, while surface patches offer slight enhancement.

Keywords:
Cardiac biomechanicsCardiac fibrosisComputational modelingComputational simulationHeart modelingRegenerative medicine

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Engineered tissue patches from induced pluripotent stem cells offer a potential treatment for severe heart failure.
  • Both surface and transmural patches are being developed, but their impact on cardiac pump function and optimal structural properties remain unclear.

Purpose of the Study:

  • To computationally investigate the mechanical impact of different cardiac tissue patch types and properties on heart function.
  • To identify key patch characteristics that can best augment existing heart tissue and improve pump performance.

Main Methods:

  • Utilized computational modeling to simulate the incorporation and function of various engineered cardiac tissue patches within a beating heart model.
  • Analyzed the effects of different patch structural properties, including active stress generation, muscle fiber alignment, and material stiffness.

Main Results:

  • Transmural patches demonstrated significant functional improvements, with activation and fiber alignment being key factors. A transmural patch generating 10% of healthy active stress increased stroke volume by 18%.
  • Higher active stress generation in a circumferential fiber orientation for transmural patches recovered stroke volume by over 50%.
  • Surface patches provided slight functional enhancement, particularly in cases of fibrotic thinning, despite potentially limiting diastolic filling.

Conclusions:

  • Specific patch designs and properties can substantially improve cardiac function in heart failure models.
  • Transmural patches with optimized active stress and fiber orientation show the greatest potential for stroke volume recovery.
  • Surface patches may offer benefits in specific cardiac conditions, highlighting the need for tailored patch engineering.