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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease V: Surgical Management01:21

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
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Related Experiment Video

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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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Ulcerative colitis: moving beyond the mucosal dogma.

Elisabeth Eggermont1, Krisztina Gecse2, Noa Krugliak Cleveland3

  • 1Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Department of Chronic Diseases and Metabolism, University Hospitals Leuven, KU Leuven, Leuven, Belgium.

The Lancet. Gastroenterology & Hepatology
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Summary
This summary is machine-generated.

Ulcerative colitis involves deeper bowel layers, not just the mucosa. These transmural changes, seen via intestinal ultrasound, may explain persistent symptoms and impact future ulcerative colitis treatment strategies.

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Area of Science:

  • Gastroenterology
  • Inflammatory Bowel Disease Research
  • Medical Imaging

Background:

  • Ulcerative colitis (UC) traditionally viewed as mucosal disease.
  • Crohn's disease (CD) characterized by transmural inflammation and fibrosis.
  • Emerging evidence suggests UC also involves deeper bowel layers.

Purpose of the Study:

  • Summarize evidence of transmural changes in UC.
  • Highlight sonographic, macroscopic, and histopathological findings.
  • Discuss implications for UC understanding and treatment.

Main Methods:

  • Review of existing sonographic, macroscopic, and histopathological data.
  • Intestinal ultrasound for in-vivo characterization of bowel wall.
  • Analysis of macroscopic and histological findings.

Main Results:

  • UC shows transmural alterations: increased bowel wall thickness, submucosal thickening, loss of stratification, haustral loss, mesenteric fibrofatty proliferation.
  • Deeper changes like colonic shortening, fibrotic strictures, and muscular remodelling observed.
  • Submucosal thickening may persist even in endoscopic remission.

Conclusions:

  • UC extends beyond the mucosa, exhibiting transmural changes.
  • These changes may contribute to persistent functional bowel symptoms.
  • Recognizing UC as a progressive transmural disease may inform future therapeutic targets.