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Hyperuricemia exacerbates acetaminophen hepatotoxicity via JNK activation and mitophagy reduction

Yan Liu1, Baizhao Peng2, Dexian Li2

  • 1Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China; The Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510180, China; School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong 510515, China.

Biochemical Pharmacology
|October 31, 2025
PubMed

Keywords:
Acetaminophen-induced hepatotoxicityC-Jun N-terminal kinaseHyperuricemiaMitophagyReactive oxygen species

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