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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

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Published on: November 13, 2016

Neuroimaging abnormalities in functional/dissociative seizures: a meta-analysis.

Maryam Homayoun¹, Alfred Pak-Kwan Lo², Benjamin Sinclair¹

¹Department of Neuroscience, The School of Translational Medicine, The Alfred Health, Monash University, Victoria, Melbourne, Australia.

Neuroscience and Biobehavioral Reviews

|October 31, 2025

Summary

This summary is machine-generated.

This study reveals structural and functional brain abnormalities in functional/dissociative seizures. Neuroimaging shows reduced cortical thickness and altered functional connectivity in key brain networks, suggesting underlying neurobiological mechanisms.

Keywords:

FDS FND MRI Meta-analysis Neuroimaging

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Area of Science:

Neuroscience
Neurology
Psychiatry

Background:

Functional/dissociative seizures present diagnostic challenges in neurology and psychiatry.
Existing neuroimaging findings for these seizures are inconsistent across studies.

Purpose of the Study:

To systematically review and meta-analyze neuroimaging abnormalities in functional/dissociative seizures.
To investigate structural (cortical thickness) and functional (resting-state functional connectivity) MRI data.

Main Methods:

Systematic review and meta-analysis of 22 studies.
Meta-analysis of cortical thickness from seven structural MRI studies.
Whole-brain, seed-based resting-state functional connectivity analysis from three functional MRI studies.

Main Results:

Reduced cortical thickness in the right calcarine fissure/cortex and right precentral gyrus.
Increased functional connectivity between sensorimotor and ventral attention networks (e.g., left thalamus, left putamen).
Heightened connectivity within the default mode network and the left insula.

Conclusions:

Functional/dissociative seizures are associated with structural and functional brain abnormalities.
These abnormalities involve visual, sensorimotor, default mode, and attentional networks.
Further research is needed to understand the complex pathophysiology, including clinical features and comorbidities.