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The Role of CD36 and Its Regulatory Mechanisms in Metabolic Dysregulation and Tumorigenesis
Chunyu Tong1, Wenzhi Feng1, Honghao Yu1
1Heilongjiang Provincial Key Laboratory of Animal Cell Activities and Stress Adaptations College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang, China.
Abstract:
Cluster of differentiation 36 (CD36) is a multifunctional membrane protein receptor widely expressed on the surface of various immune and nonimmune cells in the body, and it belongs to the class B scavenger receptor family (SR-B2). The extracellular domain of CD36 can recognise and bind to various ligands, mediating a range of biological functions and participating in various physiological and pathological processes, including immune responses, lipid metabolism, cancer and inflammation. This review summarises the gene and protein structure of CD36 and its ligand-mediated biological functions. It further elucidates the role of CD36 in regulating immune responses, various metabolic processes and mechanisms, as well as the involved signalling pathways, providing a theoretical foundation for related biological research.
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