Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

272
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
272
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

204
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
204
Positron Emission Tomography01:29

Positron Emission Tomography

6.9K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolated Ascending Aortic Aneurysms: Five-Year Comparative Outcomes between Modified Wrapping Technique and Supracoronary Tube Replacement.

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·2026
Same author

Clinical Importance of All the Characteristics of Late Gadolinium Enhancement from Acquisition to Expert and Artificial Intelligence Analysis: State-of-the-Art.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance·2026
Same author

Color K-edge image quality in spectral photon-counting CT with dual contrast agents: Toward true multi-contrast imaging.

Diagnostic and interventional imaging·2026
Same author

Comprehensive non-invasive assessment of cardiac allograft vasculopathy and myocardial involvement in heart transplant patients using cardiac computed tomography.

European journal of radiology·2026
Same author

Role of cardiovascular magnetic resonance in diagnosis and management of muscular dystrophies.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance·2026
Same author

Left and right atrioventricular coupling: state-of-the-art review.

European heart journal. Cardiovascular Imaging·2025

Related Experiment Video

Updated: Jan 12, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

4.2K

Stress myocardial perfusion imaging with photon-counting CT: Initial validation against reference modalities.

Benjamin Longère1, Hippolyte Caseneuve2, Christos V Gkizas2

  • 1Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille U1011 - European Genomic Institute for Diabetes (EGID), 59000 Lille, France; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur Lille US41 - UAR2014, 59000 Lille, France; Department of Cardiovascular Imaging, Heart and Lung Institute, University Hospital of Lille, 59000 Lille, France.

Diagnostic and Interventional Imaging
|October 31, 2025
PubMed
Summary

First-generation dual-source photon-counting CT (PCCT) offers feasible and accurate stress myocardial perfusion imaging (MPI) for detecting ischemia. This technique integrates anatomic and functional coronary assessment, potentially reducing the need for further testing.

Keywords:
Coronary artery diseaseMyocardial ischemiaMyocardial perfusion imagingPhoton-counting CTStress imaging

More Related Videos

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

20.1K
MRI and PET in Mouse Models of Myocardial Infarction
10:46

MRI and PET in Mouse Models of Myocardial Infarction

Published on: December 19, 2013

12.3K

Related Experiment Videos

Last Updated: Jan 12, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

4.2K
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

20.1K
MRI and PET in Mouse Models of Myocardial Infarction
10:46

MRI and PET in Mouse Models of Myocardial Infarction

Published on: December 19, 2013

12.3K

Area of Science:

  • Cardiovascular Imaging
  • Radiology
  • Medical Physics

Background:

  • Myocardial perfusion imaging (MPI) is crucial for diagnosing coronary artery disease (CAD).
  • Photon-counting CT (PCCT) represents a novel advancement in CT technology with potential for improved imaging performance.

Purpose of the Study:

  • To assess the feasibility and diagnostic accuracy of stress MPI using a first-generation dual-source PCCT scanner.
  • To compare PCCT-MPI performance against established reference standards for detecting myocardial ischemia.

Main Methods:

  • Consecutive patients undergoing coronary CT angiography (CCTA) and stress MPI with PCCT were included.
  • Static PCCT-MPI was performed using regadenoson and iodinated contrast, paired with delayed enhancement imaging.
  • Diagnostic performance was evaluated against reference tests like cardiac MRI, echocardiography, SPECT, or invasive angiography.

Main Results:

  • The study included 41 patients, with 85% having obstructive CAD on CCTA.
  • PCCT-MPI identified hypoperfusion in 44% of patients, with a median dose-length product of 97 mGy.cm.
  • Visual assessment showed 100% sensitivity and 96% specificity for detecting ischemic myocardium, with an AUC of 0.98. An iodine ratio cutoff achieved 98% accuracy and an AUC of 0.99.

Conclusions:

  • Stress static PCCT-MPI is feasible and highly accurate for diagnosing myocardial ischemia.
  • Spectral imaging analysis, specifically the defect-to-remote iodine ratio, further improves diagnostic performance.
  • PCCT enables a comprehensive assessment of coronary anatomy and function in a single examination at a reasonable radiation dose.