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Related Experiment Video

Updated: Jan 12, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

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Published on: May 17, 2019

Real-world data and clinical experience from over 100,000 multi-cancer early detection tests.

Marc Matrana¹, Vershalee Shukla², Dallas Kingsbury³

¹Ochsner Cancer Institute, New Orleans, LA, USA.

Nature Communications

|November 1, 2025

Summary

This summary is machine-generated.

A new blood test for multi-cancer early detection (MCED) shows real-world promise. The Galleri test identified a cancer signal in 0.91% of individuals, aiding in timely diagnosis and predicting cancer origin.

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Area of Science:

Oncology
Genomics
Diagnostics

Background:

Blood-based multi-cancer early detection (MCED) offers potential for simultaneous screening of multiple cancers.
High positive predictive value is crucial for effective early detection strategies.

Purpose of the Study:

To evaluate the real-world performance of the Galleri MCED test.
To assess the test's ability to detect cancer signals and predict cancer signal origin (CSO).

Main Methods:

Analysis of cell-free DNA methylation patterns in 111,080 individuals.
Evaluation of the Galleri MCED test's cancer signal detection rate and CSO prediction accuracy.
Tracking clinical outcomes for individuals with a detected cancer signal.

Main Results:

A cancer signal detection rate of 0.91% was observed, aligning with previous studies.
In 258 diagnosed cancers across 32 types, the MCED test correctly predicted CSO in 87% of cases.
Median time from MCED result to cancer diagnosis was 39.5 days, indicating efficient workup.

Conclusions:

The Galleri MCED test demonstrates real-world effectiveness in detecting cancer signals and predicting origin.
The test facilitates efficient diagnostic evaluation, potentially leading to earlier cancer diagnosis.
MCED tests hold significant promise for improving population-level cancer screening.