Related Experiment Video
Updated: Jan 12, 2026

09:16
Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli
Published on: April 5, 2019
11.4K
Machine learning methods on BioVid heat pain database for pain intensity estimation.
Melpo Pittara1, Andreas Anastasiou2,3, Konstantinos Andreou2,3
1Computer Science, and Artificial Intelligence, Bernoulli Institute of Mathematics, University of Groningen, Groningen, Netherlands. melpopittara@gmail.com.
Scientific Reports
|November 1, 2025
Summary
This study developed objective pain assessment using machine learning on facial expressions. Convolutional Neural Networks (CNNs) showed the highest accuracy in detecting pain intensity, offering potential for non-communicative patients.
Area of Science:
- Biomedical Engineering
- Artificial Intelligence in Healthcare
- Pain Management Research
Background:
- Traditional pain scales (NRS, VAS, VRS) are subjective and unreliable for certain patient groups.
- Objective pain assessment is crucial for accurate treatment and improved patient quality of life.
- Machine learning offers a promising avenue for developing objective pain measurement tools.
Purpose of the Study:
- To introduce and evaluate an objective pain measurement model using machine learning techniques.
- To compare the performance of Convolutional Neural Networks (CNNs), VGG16, Convolutional Vision Transformer (CvT), and MobileViT in classifying pain intensity from facial expressions.
- To assess the potential of automated pain assessment for clinical applications, especially for non-communicative patients.
Main Methods:
- Utilized facial images from the BioVid Heat Pain Database, capturing peak pain and no-pain moments.
- Trained and evaluated four machine learning models: CNN, VGG16, CvT, and MobileViT.
- Compared model performance based on accuracy in classifying pain intensity.
Main Results:
- The CNN model achieved the highest average accuracy (0.71) in classifying pain intensity.
- The CvT model demonstrated strong performance with an average accuracy of 0.69.
- VGG16 (0.56) and MobileViT50 (0.60) showed significantly lower accuracy, indicating challenges in classifying pain from facial images.
Conclusions:
- Machine learning models, particularly CNNs, show significant potential for objective and consistent pain assessment.
- Automated facial expression analysis can aid in pain evaluation for non-verbal or cognitively impaired patients.
- Future research should focus on multimodal data integration to enhance pain detection system robustness.
Related Concept Videos
Quantifying Heat
61.6K
Thermal Energy Microscopically, thermal energy is the kinetic energy associated with the random motion of atoms and molecules. Temperature is a quantitative measure of “hot” or “cold”, which depends on the amount of thermal energy. When the atoms and molecules in an object are moving or vibrating quickly, they have a higher average kinetic energy (KE) (or higher thermal energy), and the object is perceived as “hot”, or it is described as being at a higher temperature. When the...
61.6K
Blood and Nerve Supply to the Bones
13.5K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
13.5K
Pain
1.2K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.2K

