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Baseline Risk Factors and Predictive Nomogram for Short-Term Persistent Hyperuricemia Following Laparoscopic Sleeve
Yuxiao Chu1, Jian Wang2, Chong Cao1
1Center for Obesity and Hernia Surgery, Department of General Surgery, Huashan Hospital, Shanghai, China.
Obesity Surgery
|November 1, 2025
Summary
Male sex, increased waist circumference, and high baseline uric acid levels predict persistent hyperuricemia after laparoscopic sleeve gastrectomy (LSG). A developed nomogram effectively predicts this outcome, aiding clinical management.
Area of Science:
- Bariatric Surgery
- Metabolic Disorders
- Clinical Prediction Modeling
Background:
- Laparoscopic sleeve gastrectomy (LSG) is effective for obesity but has inconsistent outcomes for hyperuricemia (HUA) remission.
- Predictors for HUA persistence post-LSG require identification to improve patient management.
Purpose of the Study:
- To identify baseline predictors of HUA persistence six months after LSG.
- To develop and validate a nomogram for predicting HUA non-remission following LSG.
Main Methods:
- Retrospective analysis of 631 patients with obesity and HUA undergoing LSG.
- Logistic regression identified predictors of persistent HUA.
- A predictive nomogram was developed and externally validated using an independent cohort.
Main Results:
- Male sex, increased waist circumference (WC), and elevated baseline uric acid (UA) levels were significant predictors of persistent HUA.
- The nomogram showed excellent discriminative ability (AUC=0.85) in the training cohort.
- The nomogram maintained robust predictive performance (AUC=0.81) in the validation cohort.
Conclusions:
- Male sex, higher WC, and baseline UA levels predict persistent HUA post-LSG.
- The developed nomogram serves as a practical clinical tool for predicting short-term HUA non-remission after LSG.
