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Baseline Risk Factors and Predictive Nomogram for Short-Term Persistent Hyperuricemia Following Laparoscopic Sleeve
Yuxiao Chu1, Jian Wang2, Chong Cao1
1Center for Obesity and Hernia Surgery, Department of General Surgery, Huashan Hospital, Shanghai, China.
Introduction:
Although laparoscopic sleeve gastrectomy (LSG) effectively addresses obesity, its outcomes on hyperuricemia (HUA) remission remain inconsistent. We aimed to identify baseline predictors and develop a nomogram for HUA persistence six months following LSG.
Methods:
We retrospectively analyzed patients with obesity and HUA undergoing primary LSG at Huashan Hospital. An independent validation cohort from the Affiliated Hospital of Xuzhou Medical University was included. Clinical data, including demographics, anthropometric measurements, and biochemical markers were analyzed. Logistic regression analyses identified independent predictors of persistent HUA, and a predictive nomogram was developed and externally validated.
Results:
A total of 631 patients was enrolled in this study. Persistent HUA was observed in 41.8% (159/380) of patients in the training cohort. Multivariate analysis identified male sex (OR = 4.97, 95% CI: 2.35-10.51, P < 0.001), waist circumference (WC; OR = 1.06, 95% CI: 1.02-1.10, P = 0.006), and baseline UA levels (OR = 1.01, 95% CI: 1.01-1.02, P < 0.001) as significant predictors. The nomogram demonstrated excellent discriminative ability (AUC = 0.85, 95% CI: 0.82-0.86) and calibration. In the validation cohort, persistent HUA was observed in 35.5% (89/251), and the nomogram maintained robust predictive performance (AUC = 0.81, 95% CI: 0.76-0.82).
Conclusion:
Male sex, increased WC, and elevated baseline UA predict postoperative persistent HUA. The nomogram provides a practical clinical tool for predicting short-term HUA non-remission post-LSG.
