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Related Experiment Video

Updated: Jan 12, 2026

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Induced proximity-based therapeutic modalities.

Elizabeth A King1, Margot Meyers1, Daniel K Nomura2,3

  • 1Department of Chemistry, University of California, Berkley, Berkeley, CA, USA.

Nature Reviews. Drug Discovery
|November 1, 2025
PubMed
Summary

Induced proximity modalities, like molecular glues, enable targeted protein degradation and therapeutic intervention. Novel approaches beyond protein degradation show promise in preclinical disease models.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Proximity is crucial for biological regulation.
  • Induced proximity modalities offer therapeutic strategies beyond traditional pharmacology.
  • Molecular glues and proteolysis-targeting chimeras represent key advancements.

Purpose of the Study:

  • To survey the field of induced proximity.
  • To focus on potential therapeutic applications.
  • To discuss novel approaches for controlling cellular processes.

Main Methods:

  • Review of molecular glues and their mechanisms.
  • Analysis of heterobifunctional modalities like proteolysis-targeting chimeras.
  • Exploration of emerging strategies for cellular control.

Main Results:

  • Molecular glues enable targeted protein degradation/inhibition and have clinical applications.
  • Next-generation modalities like proteolysis-targeting chimeras show early clinical success.
  • Novel approaches target post-translational modifications, cellular localization, and transcriptional activation.

Conclusions:

  • Induced proximity is a powerful therapeutic modality.
  • Rational design of molecular glues has driven innovation in targeted protein degradation.
  • Emerging induced proximity strategies demonstrate preclinical efficacy for various diseases.