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Updated: Jan 12, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
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Reviewing the Current State of Renal Cell Carcinoma with a Tumor Thrombus: Epidemiology, Pathophysiology, Metastasis,
Maxwell Sandberg1,2, Randall Bissette3,4, Kimberly Waggener3,4
1Department of Urology, Wake Forest Baptist Medical Center, Winston Salem, NC, 27101, USA. maxwellsandberg@msn.com.
Purpose Of Review:
The purpose of this review is to highlight relevant literature on the epidemiology and pathophysiology of renal cell carcinoma with a tumor thrombus (RCC-TT), metastatic management, and the role of systemic therapy (ST).
Recent Findings:
Current research indicates different prevalences and presentations by geography, with many classification systems for RCC-TT. Pathophysiology remains poorly understood for TT formation. Some patients may benefit from cytoreductive nephrectomy with tumor thrombectomy (CN-TT) as well as ST administration, but this population is poorly defined. RCC-TT is a complex disease to manage and lacks high-powered publications relative to RCC without a TT. Future research should focus on the genetics behind TT formation and propagation, CN-TT outcomes, and which patients should receive ST and the optimal timing/dosage.
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