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Related Experiment Video

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Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
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A core-shell multifunctional microneedle patch accelerates infected diabetic wound healing.

Kang Wei1, Lu He1, Yiran Shi1

  • 1Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, 169 East Lake Road, Wuchang District, Wuhan, 430071, China.

Stem Cell Research & Therapy
|November 1, 2025
PubMed
Summary

This study introduces a novel microneedle patch for infected diabetic wounds. The patch effectively combats bacteria, reduces inflammation, and promotes healing by recruiting stem cells and enhancing blood vessel growth.

Keywords:
Diabetic wound healingInflammationMicroneedlesPalmatineSDFP

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Diabetic wounds present complex challenges including poor blood vessel formation, persistent bacterial infections, and oxidative stress.
  • Existing treatments often struggle to address these multifaceted issues effectively, necessitating innovative therapeutic approaches.

Purpose of the Study:

  • To develop and evaluate a core-shell structured multifunctional microneedle (MN) array patch (CS-SDFP/HA-Ag@MOF-PAL) for accelerated healing of infected diabetic wounds.
  • To investigate the patch's ability to target bacteria, reduce inflammation, promote stem cell recruitment, and stimulate angiogenesis.

Main Methods:

  • Design of a core-shell MN patch with a chitosan shell (CS-SDFP) and a hyaluronic acid core (HA-Ag@MOF-PAL).
  • The core contains Ag@MOF-PAL for antibacterial and anti-inflammatory effects, while the shell releases SDFP to recruit stem cells and promote healing.
  • In vivo testing on a diabetic rat model with Pseudomonas aeruginosa-infected wounds.

Main Results:

  • The CS-SDFP/HA-Ag@MOF-PAL patch demonstrated effective eradication of bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, and elimination of biofilms.
  • Palmatine (PAL) successfully mitigated chronic inflammation by modulating NF-κB and MAPK signaling pathways.
  • The patch significantly accelerated wound healing in diabetic rats by recruiting adipose-derived stem cells (ADSCs) and promoting angiogenesis.

Conclusions:

  • The developed core-shell microneedle patch is a promising multifunctional therapeutic strategy for treating infected diabetic wounds.
  • This innovative approach addresses key challenges in diabetic wound healing, offering potential for improved clinical outcomes.