Orthobiologics in the Foot and Ankle: An Update on the Current Literature

Orthobiologics continues to advance in medicine due to its regenerative capabilities. In fact, there is a vast indication of use with regenerative medicine options such as platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) within the human body for various musculoskeletal conditions. While both options are different, the purpose of each is to promote a natural healing response with specific growth factors, proteins, or cells to aid in this. In this concept review, we present a current update on the literature surrounding these regenerative medicine options specifically with utilization in the foot and the ankle. We have found in our practice that regenerative medicine options offer our patients a nonoperative as well as operative biologic supplemental option for treatment on various foot and ankle conditions with relatively high success rates and overall high patient satisfaction. We hope this review educates the foot and ankle surgeon on this rapidly evolving treatment to enhance patient outcomes and improve quality of care.Levels of Evidence:4.