Reference values for shear wave elastography, shear wave dispersion and attenuation imaging in healthy paediatric livers
Michael Zellner1, Magdalena Schmidt2, Florian Huber3
1Department of Diagnostic Imaging, University Children's Hospital Zurich, Lenggstrasse 30, Zurich, 8008, Switzerland. michael.zellner@kispi.uzh.ch.
Insights
This study establishes reference values for advanced ultrasound techniques in children, finding that age and sex influence results. These findings are crucial for accurate paediatric liver disease diagnosis using shear wave elastography (SWE), shear wave dispersion (SWD), and attenuation imaging (ATI).
Area of Science:
- Paediatric Radiology
- Hepatology
- Medical Imaging
Background:
- Paediatric liver disease, including metabolic dysfunction-associated steatotic liver disease, is increasing.
- Reliable, non-invasive diagnostic tools are needed for children.
- Advanced ultrasound techniques like shear wave elastography (SWE), shear wave dispersion (SWD), and attenuation imaging (ATI) show promise but lack normative paediatric data.
Purpose of the Study:
- To establish age-specific reference values for SWE, SWD, and ATI in healthy children.
- To evaluate the influence of age, sex, BMI, and fasting duration on these ultrasound parameters.
Main Methods:
- Retrospective analysis of ultrasound data from 264 healthy children.
- Standardized liver ultrasound protocol with multiple ATI, SWE, and SWD measurements.
- Statistical analysis to correlate imaging parameters with patient characteristics.
Main Results:
- Median ATI: 0.54 dB/cm/MHz, SWE: 1.24 m/s, SWD: 11.70 (m/s)/kHz.
- ATI and SWD negatively correlated with age; SWD also negatively correlated with BMI z-score and was lower in females.
- SWE showed a weak positive correlation with measurement depth; fasting duration had no significant impact.
Conclusions:
- Provides essential reference values for paediatric SWE, SWD, and ATI.
- Age and sex are significant factors influencing SWD and ATI.
- Emphasizes the need for age-specific interpretation of paediatric liver ultrasound findings.
Background:
The rising prevalence of paediatric liver disease, including metabolic dysfunction- associated steatotic liver disease, highlights the need for reliable, non-invasive diagnostic tools. Advanced ultrasound techniques such as shear wave elastography (SWE), shear wave dispersion (SWD), and attenuation imaging (ATI) offer promising alternatives to biopsy or magnetic resonance imaging, but normative paediatric values remain limited.
Objective:
This study aimed to establish age-specific reference values for SWE, SWD, and ATI in healthy children and to assess potential influencing factors such as age, sex, body mass index (BMI), and fasting duration.
Materials And Methods:
In this retrospective study, 264 children (135 female, median age 11.5 years) without known liver disease were selected from a cohort of 734. Each child underwent liver ultrasound using a standardized protocol with five ATI and ten SWE/SWD measurements. Only high-quality data were included. Statistical analyses examined correlations between imaging parameters and patient characteristics.
Results:
The median ATI was 0.54 dB/cm/MHz [interquartile range (IQR):0.50-0.58], SWE was 1.24 m/s (IQR:1.14-1.33) and SWD was 11.70 (m/s)/kHz (IQR:10.84-12.13). ATI and SWD values showed significant negative correlations with age (P < 0.001 and P = 0.0048, respectively). SWD also correlated negatively with BMI z-score (P < 0.001) and was significantly lower in females (P = 0.001). SWE showed only a weak positive correlation with measurement depth (P = 0.0261). Fasting duration had no significant impact on any measurement.
Conclusion:
This study provides reference values for SWE, SWD, and ATI in children. Age and sex influence SWD and ATI values, underscoring the importance of age-specific interpretation in paediatric liver ultrasound.
