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FEV1/FVC is linked to the severity of OSA in a multivariate regression analysis
Reza Erfanian1, Maryam Zare2, Reihaneh Heidari2
1Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Sleep & Breathing = Schlaf & Atmung
|November 1, 2025
Summary
A lower FEV1/FVC ratio is a significant predictor of obstructive sleep apnea (OSA) severity. Impaired lung function, indicated by this ratio, can worsen airway obstruction in OSA patients.
Area of Science:
- Pulmonary Medicine
- Sleep Medicine
- Respiratory Physiology
Background:
- Obstructive sleep apnea (OSA) involves upper airway collapse during sleep.
- Intrathoracic airways and lung volume also play a role in OSA.
- Understanding lung function's impact can help predict treatment outcomes.
Purpose of the Study:
- To investigate the role of impaired lung function in OSA severity.
- To identify predictors of OSA severity, considering lung function.
- To explore how lung function interventions might improve OSA.
Main Methods:
- 112 patients with suspected OSA underwent polysomnography and spirometry.
- Key spirometry metrics included FEV1/FVC ratio and predicted percentages.
- Multivariate regression analysis identified predictors of the apnea-hypopnea index (AHI).
Main Results:
- A lower FEV1/FVC ratio was significantly associated with a higher AHI (p < 0.001).
- Higher BMI and male gender also predicted increased AHI.
- Mild OSA patients had better FEV1/FVC ratios than severe OSA patients.
Conclusions:
- The FEV1/FVC ratio is a critical predictor of OSA severity.
- Reduced FEV1/FVC suggests airway obstruction exacerbating OSA.
- A potential shared mechanism links lower and upper airway obstruction.
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