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Updated: Jan 12, 2026

Live Imaging Assay for Assessing the Roles of Ca2+ and Sphingomyelinase in the Repair of Pore-forming Toxin Wounds
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Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling

Zhimeng Wang1, Yanfei Hou1, Peiyuan Liu2

  • 1School of Pharmaceutical Sciences, State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China; SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine, Shanxi Medical University, Taiyuan, Shanxi, China.

Immunity
|November 1, 2025
PubMed

Keywords:
SMPDL3BcGAMPcGAS-STING signaling pathwayhost-microbe interactionsinnate immunityviral infection

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