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Related Experiment Video

Updated: Jan 12, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Human immune aging.

Marina Terekhova¹, Pavla Bohacova¹, Maxim N Artyomov¹

¹Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

|November 1, 2025

Summary

This summary is machine-generated.

Investigating immune system aging reveals key changes in immune cell composition and function. Understanding these alterations is vital for healthspan and quality of life during aging.

Keywords:

adaptive immunity flow cytometry human aging immune repertoire innate immune cells single cell

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Area of Science:

Immunology
Gerontology
Cellular Biology

Background:

Aging is a fundamental biological process impacting human life and quality of life.
The immune system's role in age-related diseases is central, making immune aging a critical research area.
Distinguishing healthy from dysfunctional immune aging offers insights into system failure mechanisms.

Purpose of the Study:

To review current knowledge on human immune aging.
To examine alterations in immune cell composition and function in circulation and tissues.
To discuss the evolution and complementarity of cytometry techniques in studying immune aging.

Main Methods:

Review of existing literature on human immune aging.
Analysis of changes in major immune compartments (circulation and tissues).
Comparison of findings from flow cytometry, single-cell, and advanced cytometry techniques.

Main Results:

Significant changes occur in the composition and function of immune cells during aging.
Both circulation and tissue-resident immune compartments are affected.
Different cytometry techniques provide complementary data, but discrepancies need exploration.

Conclusions:

Understanding human immune aging is crucial for improving healthspan and quality of life.
Advanced cytometry methods enhance our ability to study immune aging.
Further research is needed to address persistent challenges in the field of immune aging.