Related Experiment Video
Updated: Jan 12, 2026

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
Advances in the construction and application of transdermal delivery systems
Xiaofeng Miao1, Chenxu Du1, Weiqi Wang1
1State Key Laboratory of Crop Stress Adaptation and Improvement, College of Agriculture, Henan University, Kaifeng 475004, China; Food Laboratory of Zhongyuan, Luohe 462300, China.
Abstract:
In recent years, transdermal drug delivery has become a significant research focus for novel drug delivery methods. The primary challenge lies in overcoming the stratum corneum barrier, which impedes drug penetration. Enhancing drug transmittance and bioavailability and effectively breaching the skin barrier are critical challenges in developing transdermal methods. This paper reviews the principles and applications of various enhancement techniques, including penetration enhancers, microneedles, and advanced systems such as liposomes, electroporation, and iontophoresis. It compares the advantages and disadvantages of these systems and discusses future directions for transdermal delivery. The aim is to assist researchers in advancing transdermal delivery systems.
More Related Videos
11:07Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
10:33A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
Published on: February 23, 2018
Related Concept Videos
Drug Delivery: Overview
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Non-Oral Extravascular Drug Absorption Routes
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Bioavailability Enhancement: Drug Permeability Enhancement
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Drug Delivery: Enteral Route