Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

What is Monogastric Digestion?

What is Monogastric Digestion?

The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Historical roots of hospital-centred operational governance in China: a path dependence analysis and its implications for global health system reform.

BMJ global health·2026

Same author

Environmental Health Literacy Prevalence and Profiles among Shanghai Residents - Shanghai, China, 2020-2024.

China CDC weekly·2026

Same author

Evaluating deep coal rock gas fracturing sweet spot intervals using PSO-ELM algorithm and petrophysical logging data.

Scientific reports·2026

Same author

Association of body mass index and serum markers with immune-related adverse events in lung cancer patients receiving immune checkpoint inhibitors.

Journal of thoracic disease·2026

Same author

Co- and Multi-Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review.

Movement disorders : official journal of the Movement Disorder Society·2026

Same author

An In-Depth Exploration of the Impact of Mixing Ratios in Ball Milling on the Performance of Carbon-Coated LiFe<sub>0.5</sub>Mn<sub>0.5</sub>PO<sub>4</sub> and NCM811 Cathode Material Composites.

Chemphyschem : a European journal of chemical physics and physical chemistry·2026

Search research articles

Related Experiment Video

Updated: Jan 6, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Associations between gut microbiota and multiple system atrophy: a Mendelian randomization study.

Duo Wang^1,2,3, Yuan-Yuan Zhao², Yue Huang^4,5

¹Affiliated Hospital of Hebei University/School of Clinical Medicine of Hebei University, Baoding, China.

Journal of Neurology

|November 2, 2025

Summary

This summary is machine-generated.

This study used Mendelian randomization to investigate the causal link between gut bacteria and Multiple System Atrophy (MSA). Certain gut bacteria were associated with increased or decreased MSA risk, suggesting potential therapeutic targets.

Keywords:

Genetic epidemiology Gut microbiota Mendelian randomization Microbiome Multiple system atrophy Neurodegeneration

More Related Videos

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

Murine Fecal Isolation and Microbiota Transplantation

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

Related Experiment Videos

Last Updated: Jan 6, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

Murine Fecal Isolation and Microbiota Transplantation

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

Area of Science:

Neuroscience
Microbiology
Genetics

Background:

Multiple System Atrophy (MSA) is a rare, progressive neurodegenerative disease impacting motor control and autonomic function.
The gut microbiome's role in neurodegeneration is increasingly recognized, but causal links to MSA remain unproven.

Purpose of the Study:

To investigate potential causal relationships between specific gut bacterial taxa and the risk of developing Multiple System Atrophy (MSA).
To leverage Mendelian randomization (MR) to infer causality from observational data on gut microbiota and MSA.

Main Methods:

A two-sample Mendelian randomization (MR) analysis was performed using genome-wide association study (GWAS) data for 196 gut microbial taxa and MSA.
Inverse-variance weighting was the primary MR method, with complementary analyses including weighted median, MR-Egger, and MR-PRESSO.
Sensitivity analyses were conducted to assess potential pleiotropy and heterogeneity, ensuring the robustness of the findings.

Main Results:

Six bacterial taxa exhibited nominal associations with MSA risk.
Lentisphaeria, Oscillospira, Victivallales, and Peptococcus were linked to an increased risk of MSA.
Veillonella and Erysipelotrichaceae UCG-003 were associated with a reduced risk of MSA.
No significant pleiotropy or heterogeneity was detected, though no associations survived multiple-testing correction.

Conclusions:

This MR study provides preliminary evidence suggesting potential causal links between specific gut bacteria and MSA.
The identified taxa represent potential microbial targets for future research into MSA mechanisms and treatments.