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Updated: Jan 12, 2026
Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation
Published on: June 16, 2023
Phytotherapy for chronic wound management in the era of antibiotic resistance
1Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India.
Background:
Chronic wounds, which exhibit prolonged inflammation, impaired healing, and vulnerability to infections, remain a global health challenge, largely driven by the persistence of microbial biofilms and escalating antimicrobial resistance (AMR). Biofilm protects pathogens from the host's immune defenses and conventional antibiotic treatments, sustaining wound chronicity and fostering resistance. Due to the inefficacy of traditional antibiotics in penetrating biofilms and mitigating resistant strains, alternative therapeutic strategies are urgently required.
Objective:
To review the literature on the use of phytocompounds in chronic wound care.
Methods:
Various databases such as PubMed, Google Scholar, and Web of Science were thoroughly surveyed by using keywords "phytocompounds, chronic wounds, wound healing, antimicrobial activity, antibiofilm activity and phytotherapy."
Results:
Findings indicate that the compounds, such as flavonoids, terpenoids, and alkaloids, target various biological pathways, disrupt quorum sensing, and suppress virulence factors, making them valuable for disrupting biofilms and managing AMR. Phytocompounds such as coumarin, tannic acid, resveratrol, and berberine have the potential to enhance wound healing by reducing oxidative stress, promoting clotting, stimulating collagen synthesis, and combating infection. This review highlights complications associated with chronic wounds and explores beneficial phytocompounds for their management.
Conclusion:
Phytotherapy may play a role in managing wounds by promoting healing, preventing infection, and reducing the need for resistant antibiotics. Combining natural agents with traditional treatments presents a novel and integrative pathway to overcome the limitations posed by antibiotic resistance and biofilm-associated chronicity. While current findings are promising, further validation is needed to fully establish their clinical applications.
Insights
Phytocompounds show promise in treating chronic wounds by combating biofilms and antimicrobial resistance (AMR). These natural compounds enhance healing and reduce reliance on conventional antibiotics, offering a new therapeutic avenue.
Area of Science:
- Natural Product Chemistry
- Wound Healing Research
- Antimicrobial Therapeutics
Background:
- Chronic wounds pose a global health challenge due to persistent biofilms and increasing antimicrobial resistance (AMR).
- Biofilms protect microbes from immune responses and antibiotics, prolonging wound healing and driving resistance.
- Current antibiotics are often ineffective against biofilms and resistant strains, necessitating alternative treatments.
Purpose of the Study:
- To conduct a literature review on the therapeutic potential of phytocompounds in managing chronic wounds.
- To explore the role of plant-derived compounds in addressing biofilm formation and antimicrobial resistance in wound care.
Main Methods:
- A comprehensive literature search was performed across PubMed, Google Scholar, and Web of Science.
- Keywords included "phytocompounds," "chronic wounds," "wound healing," "antimicrobial activity," "ant biofilms activity," and "phytotherapy."
Main Results:
- Phytocompounds like flavonoids, terpenoids, and alkaloids target microbial pathways, disrupt quorum sensing, and reduce virulence factors, aiding in biofilm disruption and AMR management.
- Specific compounds (coumarin, tannic acid, resveratrol, berberine) promote wound healing by reducing oxidative stress, enhancing clotting, stimulating collagen synthesis, and fighting infection.
- The review details chronic wound complications and identifies beneficial phytocompounds for their treatment.
Conclusions:
- Phytotherapy offers a potential strategy for chronic wound management, promoting healing and preventing infections while reducing the need for resistant antibiotics.
- Integrating natural agents with conventional treatments presents an innovative approach to overcome challenges of antibiotic resistance and biofilm-associated chronicity.
- Further clinical validation is required to fully establish the therapeutic applications of phytocompounds in wound care.
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