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The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
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Deep ensemble model with blockchain technology for lung cancer detection with secured data sharing.

Hari Krishna Kalidindi1, N Srinivasu1

  • 1Department of Computer Science and Engineering, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh 522502, India.

Computational Biology and Chemistry
|November 2, 2025
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Summary

This study introduces a novel framework for secure and accurate lung cancer detection using a hybrid deep learning model (HCNN-ALSTM) optimized by the Modified Krill Herd Algorithm (MKHA). The system enhances early diagnosis from CT scans while ensuring patient data privacy through blockchain technology.

Keywords:
Blockchain TechnologyHybrid Convolutional Neural Network with Autoencoder and Long Short-Term MemoryLung Cancer DetectionModified Krill Herd AlgorithmSecured Data Sharing

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Area of Science:

  • Medical Imaging
  • Artificial Intelligence
  • Blockchain Technology

Background:

  • Lung cancer diagnosis is often delayed, leading to high mortality rates.
  • Existing methods struggle with feature extraction from CT scans and lack secure data sharing.
  • Centralized medical data systems pose risks of breaches and tampering.

Purpose of the Study:

  • To propose a secure and efficient framework for lung cancer detection.
  • To enhance early diagnosis accuracy using advanced deep learning techniques.
  • To ensure privacy-preserving sharing of sensitive medical data.

Main Methods:

  • Utilized CT scan data from benchmark datasets.
  • Implemented blockchain with smart contracts for secure, decentralized data management.
  • Developed a Hybrid Convolutional Neural Network with Autoencoder and Long Short-Term Memory (HCNN-ALSTM) for feature extraction.
  • Optimized the HCNN-ALSTM model using the Modified Krill Herd Algorithm (MKHA).

Main Results:

  • The MKHA-HCNN-ALSTM model achieved 91.64% accuracy, outperforming existing models.
  • Achieved high specificity (92.2%), MCC (84.17), FM (92.44), BM Informedness (84.2), and Markedness (84.13).
  • Demonstrated effective feature extraction and parameter optimization for improved diagnostic accuracy.

Conclusions:

  • The proposed framework offers a secure and effective solution for early lung cancer detection.
  • Blockchain ensures privacy-preserving data sharing among healthcare institutions.
  • The MKHA-HCNN-ALSTM model shows significant potential for clinical decision-making and patient care.