Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cross-reactivity

Cross-reactivity

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The pyroptosis cascade between inflammatory endothelial cells and microglia facilitates BBB disruption in bacterial meningitis.

Cell reports·2026

Same author

Spatiotemporal dynamics of reactive oxygen species: implications for cellular homeostasis and redox therapies.

Cellular & molecular biology letters·2026

Same author

The applications of single-cell multiomics in drug screening.

Pharmaceutical science advances·2026

Same author

A Protocol for Constructing a Mouse Model of Hypertensive Myocardial Fibrosis Using Angiotensin II.

Journal of visualized experiments : JoVE·2025

Same author

A biomechanical study of a novel multi-plane elastic fixation anchor screw for the distal tibiofibular syndesmosis.

International journal of surgery (London, England)·2025

Same author

Comparative study of stigma and social participation in older people with different levels of hearing impairment.

Geriatric nursing (New York, N.Y.)·2025

Search research articles

Related Experiment Video

Updated: Jan 12, 2026

Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS

Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS

Published on: April 13, 2016

Associations between circulating multiple metals and immunoglobulin levels: A cross-sectional study.

Yuying Wen¹, Hanyu Hu¹, Yufei Wang¹

¹Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Ecotoxicology and Environmental Safety

|November 2, 2025

Summary

Environmental metal exposure, including arsenic, lead, and thallium, is linked to reduced immunoglobulin A (IgA). Conversely, copper, molybdenum, vanadium, and zinc show associations with increased immunoglobulin G (IgG) and immunoglobulin E (IgE).

Keywords:

Humoral immune function Metal Serum immunoglobulin

More Related Videos

Developing a Salivary Antibody Multiplex Immunoassay to Measure Human Exposure to Environmental Pathogens

Developing a Salivary Antibody Multiplex Immunoassay to Measure Human Exposure to Environmental Pathogens

Published on: September 12, 2016

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography

Published on: January 17, 2020

Related Experiment Videos

Last Updated: Jan 12, 2026

Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS

Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS

Published on: April 13, 2016

Developing a Salivary Antibody Multiplex Immunoassay to Measure Human Exposure to Environmental Pathogens

Developing a Salivary Antibody Multiplex Immunoassay to Measure Human Exposure to Environmental Pathogens

Published on: September 12, 2016

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography

Published on: January 17, 2020

Area of Science:

Environmental Health
Immunology
Toxicology

Background:

Metals/metalloid exposure is linked to adverse health outcomes.
The impact of metals on humoral immunity is not well understood.
This study investigates metal-body burden and serum immunoglobulin levels.

Purpose of the Study:

To examine the association between plasma metal concentrations and serum immunoglobulin (Ig) levels (IgA, IgG, IgM, IgE).
To explore dose-response relationships and potential effect modifications.

Main Methods:

Cross-sectional study of 3093 participants.
Plasma metal levels measured by ICP-MS; serum Ig levels by immunoturbidimetry.
Generalized linear regression and restricted cubic spline models used.

Main Results:

Arsenic, lead, and thallium associated with lower IgA.
Copper, molybdenum, vanadium linked to higher IgG; zinc to higher IgE.
Significant modifications by gender, age, and drinking status observed.

Conclusions:

Specific metal exposures correlate with distinct humoral immunity alterations.
Findings suggest environmental metals may play a role in immune dysregulation.
Reductions in IgA and increases in IgG/IgE highlight potential health risks.