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A little "BiTS" of LAG3 agonism, a big effect on T-cell autoimmunity

Qianqian Ming1, Vincent C Luca1

  • 1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.

Immunology and Cell Biology
|November 2, 2025
PubMed

LAG3-MHC-II binding recruits LAG3 to the immune synapse, suppressing T-cell activation through induced formation of condensates between the LAG3 intracellular domain and that of the CD3ε subunit. The BiTS molecule designed by Du et al. mimics the effect of MHC-II binding by tethering LAG3 to the TCR.

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