Frequency of, and prognostic factors for, residual thrombosis and complete veno-occlusion following anticoagulation for provoked venous thromboembolism in patients <21 years: findings from the Kids-DOTT Multinational Trial
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View abstract on PubMed
Summary
This summary is machine-generated.Nearly 29% of pediatric patients had residual thrombosis (RT) and 13% had complete veno-occlusion (CVO) after 6 weeks of anticoagulation. VTE location and infection predicted these outcomes.
Area Of Science
- Pediatric Thrombosis Research
- Vascular Medicine
- Clinical Trial Analysis
Background
- Prognostic factors for residual thrombosis (RT) and complete veno-occlusion (CVO) following acute venous thromboembolism (VTE) in children are not well-defined.
- Understanding these factors is crucial for managing pediatric VTE and preventing long-term complications.
Purpose Of The Study
- To determine the frequency of RT and CVO in pediatric patients after 6 weeks of anticoagulation.
- To identify predictors associated with the presence of RT and CVO in this population.
Main Methods
- A secondary analysis of the Kids-DOTT randomized clinical trial was conducted.
- Radiological assessments for RT and CVO were performed at 6 weeks post-VTE diagnosis.
- Univariate and multivariable logistic regression analyses identified significant predictors (P < .05).
Main Results
- Among 532 pediatric patients, 28.8% had RT and 12.6% had CVO at 6 weeks.
- Cerebral venous sinus VTE location (OR, 2.52) and comorbid infection (OR, 1.61) predicted RT.
- Internal jugular vein VTE (OR, 3.97) and lower extremity VTE (OR, 2.28) predicted CVO.
Conclusions
- A significant proportion of pediatric patients experience RT and CVO after initial anticoagulation.
- VTE location and comorbid infection are key predictors of these outcomes.
- Further research is needed to understand the long-term sequelae of RT and CVO in pediatric VTE, including post-thrombotic syndrome and quality of life.
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