Related Experiment Videos

Homocitrate synthase as the crucial site of the lysine effect on penicillin biosynthesis

C G Friedrich, A L Demain

The Journal of Antibiotics

|September 1, 1977

Abstract:

Homocitrate reverses the lysine inhibition of penicillin bisynthesis. Since lysine is known to inhibit homocitrate synthase, reversal by the reaction product identifies this enzyme as the crucial site of the lysine effect.

Related Concept Videos

Articles linked to this work by shared authors, journal, and citation graph.

Studies on the overproduction of indole-containing metabolites by a methanol-utilizing yeast : Hansenula polymorpha.

Applied biochemistry and biotechnology·2013

Antimicrobials, drug discovery, and genome mining.

Applied microbiology and biotechnology·2012

Properties of acetate kinase activity in Clostridium thermocellum cell extracts.

Applied biochemistry and biotechnology·2008

Tetanus toxin production in soy-based medium: nutritional studies and scale-up into small fermentors.

Letters in applied microbiology·2007

Menstrum for culture preservation and medium for seed preparation in a tetanus toxin production process containing no animal or dairy products.

Letters in applied microbiology·2006

Small bugs, big business: the economic power of the microbe.

Biotechnology advances·2003

See all related articles