Related Experiment Video
Updated: Jan 12, 2026

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
Anal Squamous Intraepithelial Lesions: A Primer for Gastroenterologists
Brennan Gioe1, Shilpa Jain2, Waqar Qureshi3
1Department of Medicine, Gastroenterology, Baylor College of Medicine, Houston, USA.
Purpose Of Review:
The purpose of this review is to provide gastroenterologists a basic understanding of what anal squamous intraepithelial lesions (ASILs) are, how they develop, who are the high-risk populations, who and how to screen, and management of these lesions.
Recent Findings:
Human papilloma virus (HPV) infection is the most common cause of squamous cell carcinoma of the anus. Anal intraepithelial neoplasia is a precursor to the development of anal squamous cell carcinoma, and screening can lead to early detection and cure. Despite the availability of HPV vaccination for primary prevention, the mortality from squamous cell carcinoma of the anus continues to rise. ASILs are precursor lesions to anal cancer, and with proper detection and treatment, the risk of anal cancer progression can be lessened. We discuss the screening and surveillance of these lesions, and their further management when high-grade dysplasia or cancer develops.
More Related Videos
Related Concept Videos
Barrett Esophagus-I: Introduction
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Mucosal Barrier of the Stomach
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Serum Laboratory Studies, Stool Test, Breath Test

