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Chronic myelomonocytic leukaemia
Ayalew Tefferi1, Mrinal M Patnaik1
1Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Abstract:
Chronic myelomonocytic leukaemia (CMML) is a morphological hybrid between myelodysplastic and myeloproliferative neoplasms and is characterized by clonal monocytosis. Myeloid neoplasm-associated somatic mutations are present in >90% of patients with CMML but are not diagnostically specific but a subset are prognostically relevant. Current drug therapy in CMML is mostly palliative and not disease-modifying. Allogeneic haematopoietic stem cell transplantation is a potentially curative treatment modality in CMML and its timing is determined by formal prognostic models including the recently developed BLAST and BLAST-molecular risk models.
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