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Interaction-Specific Control Over Self-Assembly Landscape and Supramolecular Chirality.

Sayan Bhattacharjee1, Triza Pal1, Utkarsh Mall1

  • 1Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur, 741246, India.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|November 3, 2025
PubMed
Summary
This summary is machine-generated.

Researchers precisely control supramolecular chirality in molecular assemblies by selectively disabling hydrogen bonds. This allows deterministic guidance of self-assembly into specific chiral states, offering new molecular design possibilities.

Keywords:
H‐bonding interactionschiral inversioncooperative interactionspathway complexitystereomutation

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Organic Chemistry

Background:

  • Supramolecular chirality arises from cooperative noncovalent interactions.
  • Manipulating individual interactions can influence overall assembly and chirality.
  • Controlling complex self-assembly landscapes remains a significant challenge.

Purpose of the Study:

  • To demonstrate interaction-specific control over supramolecular chirality.
  • To guide the aqueous self-assembly of enantiomeric perylene bisimides into distinct chiral states.
  • To achieve deterministic control over complex self-assembly processes.

Main Methods:

  • Utilizing a pair of enantiomeric perylene bisimides for self-assembly studies.
  • Employing specific heating/cooling protocols and varying water-cosolvent ratios to access different chiral states.
  • Selectively and reversibly disabling carboxylic acid-mediated hydrogen bonding interactions.

Main Results:

  • Each enantiomer self-assembled into three distinct chiral states, including mirror-image structures.
  • Selective disruption of hydrogen bonds allowed deterministic guidance of assembly into specific chiral states.
  • The strategy was successfully applied to structurally related molecules, demonstrating generality.

Conclusions:

  • Selective manipulation of noncovalent interactions provides unprecedented control over supramolecular chirality.
  • This approach enables deterministic guidance of molecular self-assembly.
  • The findings offer a powerful strategy for designing and controlling chiral molecular architectures.