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Biofilm-Antagonist Ginger-Based 3D-Printable Photoresins for Complex Implant Designs Exhibiting Advanced
Simran Jindal1, Majd Bisharat1, Bassma Khamaisi1
1The Laboratory for Advanced Functional/Medicinal Polymers & Smart Drug Delivery, Technologies, The Wolfson Faculty of Chemical Engineering, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.
Advanced Materials (Deerfield Beach, Fla.)
|November 3, 2025
Summary
Researchers developed novel 3D-printable resins from ginger-derived Zingerol (Zing-OH). These biocompatible materials show excellent anti-biofilm properties, offering promising solutions for bone-tissue engineering and reducing implant rejection.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Biotechnology
Background:
- 3D-printing enables personalized implants but faces challenges like immune response and infection.
- Developing biocompatible and functional materials is crucial for advanced medical applications.
- Ginger-derived compounds offer potential for novel biomaterial development.
Purpose of the Study:
- To create novel 3D-printable resins using Zingerol (Zing-OH) from ginger.
- To investigate the properties and biocompatibility of these ginger-based resins for bone-tissue engineering.
- To address challenges in implant design, host response, and infection prevention.
Main Methods:
- Chemically modifying Zingerol (Zing-OH) into photopolymerizable resins (ether, ester, urethane).
- Utilizing Digital Light Processing (DLP) 3D-printing for high-resolution complex designs.
- Evaluating thermal, mechanical, biodegradation, hemocompatibility, and cyto-compatibility properties.
- Conducting in vivo biocompatibility studies in a rat model and assessing anti-biofilm efficacy.
Main Results:
- Successfully synthesized unique Zing-OH-based photopolymerizable resins.
- Achieved high-resolution 3D prints with tunable thermal, mechanical, and biodegradation properties.
- Demonstrated excellent hemocompatibility and cyto-compatibility with human and mouse cell lines.
- Confirmed in vivo biocompatibility in rats over 28 days with no severe inflammatory response.
- Exhibited significant anti-biofilm and antioxidant properties.
Conclusions:
- Ginger-derived Zing-OH can be formulated into advanced 3D-printable resins.
- These materials possess tunable properties, bone-mimicking mechanical strength, and excellent biocompatibility.
- The anti-biofilm and antioxidant capabilities make them highly promising for bone-tissue engineering (BTE) applications.
- The developed resins offer a novel approach to mitigate implant rejection and infection.
