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Updated: Jan 12, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Regioselective postmodification of aryl sulfonyl fluorides via iridium(I)-catalysed C-H borylation
Shuting Wang1, Shuai Tang1, Xiao-Le Han1
1Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education and Hubei Key Laboratory of Catalysis and Materials Science, School of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, P. R. China. HXL1220@hotmail.com.
Abstract:
Borylated aryl sulfonyl fluorides are versatile building blocks, demonstrating selective chemoselectivity in a variety of transformations. This work presents an efficient iridium-catalysed C-H borylation method for the regioselective synthesis of borylated aryl sulfonyl fluorides. The approach offers scalability to gram quantities and facilitates the conversion of both the boron and sulfonyl fluoride groups into diverse functional groups, enabling rapid access to key bioactive molecules.
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