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Updated: Jan 12, 2026

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro
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Triple-Negative Breast Cancer Cells Resist Natural Killer Cell-Mediated Killing Through Interleukin-11

Hongmei Yang1, Hao Jia1, Renfei Wu1

  • 1Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macao SAR, 999078, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 3, 2025
PubMed
Summary

Triple-negative breast cancer (TNBC) cells resist natural killer (NK) cell attacks by secreting interleukin-11 (IL-11). This IL-11 pathway inhibits NK cell function, promoting immune evasion. Targeting IL-11 may improve NK cell therapies for TNBC.

Keywords:
IL‐11NK cell exhaustionTNBCimmune evasiontrans‐signaling

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