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Related Concept Videos

Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
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Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

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Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Surface Membrane Barriers01:18

Surface Membrane Barriers

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The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
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Related Experiment Video

Updated: Jan 12, 2026

Author Spotlight: Advancements in Understanding and Combatting Shigella Infections
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Author Spotlight: Advancements in Understanding and Combatting Shigella Infections

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How Shigella tackles host defences.

Yizhou Huang1, Teresa L M Thurston1

  • 1Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.

Elife
|November 3, 2025
PubMed
Summary

Shigella bacteria evade host defenses by destroying RNF213, a key protein that detects intracellular pathogens. This degradation allows the bacteria to survive undetected within host cells.

Area of Science:

  • Microbiology
  • Immunology
  • Cell Biology

Background:

  • Pathogenic bacteria like *Shigella* pose significant threats to host health.
Keywords:
RNF213Shigellaautophagybacteriologyimmunologyinfectious diseaseinflammationmicrobiologyubiquitinxenophagy

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  • Effective host immune responses rely on the detection of intracellular pathogens.
  • RNF213 is a crucial host protein involved in sensing microbial invaders within cells.