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A GSH-consuming nanoamplifier for synergistic SO2 gas therapy and ferroptosis promotion
Fengqin Wang1, Yan Miao2, Jiawen Yang2
1Nantong Institute of Technology, Nantong, Jiangsu 226006, China.
Abstract:
A hyaluronic acid-modified nanotheranostic platform (Fe-DALN@HA) was constructed via Fe3+-coordinated self-assembly of a GSH-responsive SO2 prodrug, enabling tumor-targeted delivery and synergistic induction of gas-enhanced ferroptosis through SO2 gas release and the Fenton reaction for effective cancer therapy.
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