Related Experiment Video

Updated: Jan 12, 2026

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.7K

Recent advances of circular RNAs in gastrointestinal cancer

Long-Fei Xie1,2,3,4, Sheng-Yan Liu1,2,3,4, Xiao-Wei Dang1,2,3,5

  • 1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.

World Journal of Clinical Oncology
|November 3, 2025
PubMed

Insights

Circular RNAs (circRNAs) are key non-coding RNAs influencing digestive system cancers. This review explores their roles as biomarkers and therapeutic targets in esophageal, gastric, and colorectal cancers.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Non-coding RNAs regulate cellular signals.
  • Circular RNAs (circRNAs) are a distinct class of non-coding RNAs with unique structures.
  • circRNAs are increasingly recognized for their roles in cancer development.

Purpose of the Study:

  • To review the current research on circRNAs in digestive system cancers.
  • To explore the potential of circRNAs as biomarkers and therapeutic targets.
  • To discuss the involvement of circRNAs in immune modulation and chemoresistance.

Main Methods:

  • Literature review of recent research on circRNAs in gastrointestinal cancers.
  • Analysis of circRNA functions in tumor initiation and progression.
  • Synthesis of findings regarding circRNAs' roles in esophageal, gastric, hepatic, pancreatic, and colorectal cancers.

Main Results:

  • circRNAs significantly impact the initiation and progression of digestive system cancers.
  • circRNAs show potential as diagnostic biomarkers and therapeutic targets.
  • circRNAs are implicated in modulating the tumor immune microenvironment and influencing chemoresistance.

Conclusions:

  • circRNAs play critical roles in the pathogenesis of digestive system cancers.
  • Further research into circRNAs could lead to novel diagnostic and therapeutic strategies.
  • Understanding circRNAs is crucial for advancing gastrointestinal oncology.
Keywords:
BiomarkerCircRNAsGastrointestinal cancerImmune modulationSignal pathway

More Related Videos

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

2.0K
Use of Alu Element Containing Minigenes to Analyze Circular RNAs13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.7K

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
7.2K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
6.8K