Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

COPD: Pathogenesis and Clinical Features

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

COPD: Management Using Bronchodilators and Corticosteroids

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

Chronic Obstructive Pulmonary Disease-V: Management

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cardiovascular events in patients with COPD after long-acting bronchodilator initiation.

ERJ open research·2026

Same author

Urban greenspace and dementia: Measures, mechanisms, and methodological guidance.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same author

Reproducibility of the 6-Minute Walk Test on a 20-Metre Course in Community Dwelling Adults With Chronic Obstructive Pulmonary Disease.

Physiotherapy Canada. Physiotherapie Canada·2026

Same author

Association of Air Pollution With Brain Health: A Cross-Sectional Analysis of Adults Living in Canada.

Stroke·2026

Same author

Poor Sleep Quality and Heightened Perceptual Responses to Exercise in Community Dwellers: Results from the CanCOLD Study.

Annals of the American Thoracic Society·2026

Same author

Reply: Why fan therapy does not yet demonstrate enhanced training benefits in people with chronic respiratory disease.

The European respiratory journal·2026

Same journal

The epidemiological burden and societal cost of 14 respiratory conditions in the World Health Organization European region: systematic evidence map and economic analysis.

ERJ open research·2026

Same journal

Menthol inhalation relieves dyspnoea through the brain.

ERJ open research·2026

Same journal

Understanding the perceptions and experiences of adults with early-onset neuromuscular disorders using noninvasive ventilation in making healthcare decisions.

ERJ open research·2026

Same journal

Exploring glucocorticoid receptor signalling in lymphangioleiomyomatosis.

ERJ open research·2026

Same journal

Senescence intensifies bleomycin-induced injury in idiopathic pulmonary fibrosis lung epithelial cells.

ERJ open research·2026

Same journal

Absolute and relative intensity of physical activity after lung cancer surgery.

ERJ open research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 12, 2026

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

Clinically important deterioration in a mild-moderate COPD population.

Sharmistha Biswas¹, Dany Doiron¹, Pei Zhi Li¹

¹Respiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.

ERJ Open Research

|November 3, 2025

Summary

This summary is machine-generated.

Clinically Important Deterioration (CID) predicts worsening COPD outcomes, particularly exacerbations and health status decline. Focusing on exacerbation history and health status, rather than lung function alone, is recommended for predicting COPD progression.

More Related Videos

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Published on: August 18, 2023

Related Experiment Videos

Last Updated: Jan 12, 2026

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Published on: August 18, 2023

Area of Science:

Pulmonary Medicine
Chronic Obstructive Pulmonary Disease (COPD) Research
Clinical Epidemiology

Background:

Clinically Important Deterioration (CID) is a composite outcome measuring disease worsening in COPD.
Previous studies focused on moderate-severe COPD populations.
The predictive value of CID in mild-moderate COPD requires further investigation.

Purpose of the Study:

To assess if Clinically Important Deterioration (CID) predicts disease worsening over 18 months in a population-based cohort of individuals with mild-moderate COPD.
To examine the association between CID components and future COPD exacerbations and health status decline.

Main Methods:

Utilized data from the Canadian Cohort Obstructive Lung disease (CanCOLD) study.
Assessed participants for CID over 18 months and subsequent outcomes over the next 18 months.
Employed logistic regression, Cox proportional hazards, and Poisson regression models to analyze associations between CID and outcomes like exacerbations, lung function (FEV1), and health status (SGRQ, CAT).

Main Results:

60% of participants (252/420) experienced CID.
CID was associated with future moderate/severe exacerbations (though not statistically significant), worsening health status (CAT score), and dyspnea.
Exacerbations and health status components (SGRQ, CAT) were more informative predictors of future health status decline than FEV1 decline.

Conclusions:

CID components, particularly exacerbation history and health status, are valuable for predicting future outcomes in mild-moderate COPD.
Clinical assessments should prioritize exacerbation history and health status over solely relying on airway obstruction severity.
Adaptations to the current CID definition may be necessary for application in mild-moderate COPD populations.