Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Injectable anti-inflammatory, antioxidant supramolecular nanofiber hydrogel for peripheral nerve injury repair and neuropathic pain relief.

Materials today. Bio·2026
Same author

CXCL7/CXCR2 in the paraventricular thalamus mediates obesity-related pain.

Journal of neuroinflammation·2026
Same author

Exploring the mechanism of PFTrDA on human hepatic metabolic diseases based on network toxicology and molecular docking.

Scientific reports·2025
Same author

Chain Length-Dependent Inhibition of Human and Rat Placental Aromatase by Benzalkonium Disinfectants: Experimental, Quantitative Structure-Activity Relationship, and In Silico Docking Insights.

Environmental science & technology·2025
Same author

Isothiazole Disinfectants Inhibit Neurosteroid Production by Targeting Human and Rat 5α-Reductase Type 1.

Chemical research in toxicology·2025
Same author

Halogen Atoms in Bisphenol A Derivatives Enhance the Inhibitory Potency against Human and Rat Placental 3β-Hydroxysteroid Dehydrogenases.

Chemical research in toxicology·2025

Related Experiment Video

Updated: Jan 12, 2026

In Vivo Alkaline Comet Assay and Enzyme-modified Alkaline Comet Assay for Measuring DNA Strand Breaks and Oxidative DNA Damage in Rat Liver
10:38

In Vivo Alkaline Comet Assay and Enzyme-modified Alkaline Comet Assay for Measuring DNA Strand Breaks and Oxidative DNA Damage in Rat Liver

Published on: May 4, 2016

16.2K

Perfluoroundecanoic Acid Inhibits Liver Cell Development in Pubertal Male Rats via Inducing Oxidative Stress.

Zengqiang Li1,2, Chaoqun Guo3, Xinyi Ye1,2

  • 1Department of Anesthesiology, Anesthesiology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.

ACS Omega
|November 3, 2025
PubMed
Summary

Perfluoroundecanoic acid (PFUnA) exposure significantly impacts pubertal rat liver development. PFUnA disrupts lipid metabolism and induces oxidative stress, potentially inhibiting liver growth during this critical period.

More Related Videos

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
09:27

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

3.9K
A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
08:35

A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium

Published on: May 18, 2021

7.4K

Related Experiment Videos

Last Updated: Jan 12, 2026

In Vivo Alkaline Comet Assay and Enzyme-modified Alkaline Comet Assay for Measuring DNA Strand Breaks and Oxidative DNA Damage in Rat Liver
10:38

In Vivo Alkaline Comet Assay and Enzyme-modified Alkaline Comet Assay for Measuring DNA Strand Breaks and Oxidative DNA Damage in Rat Liver

Published on: May 4, 2016

16.2K
Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
09:27

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

3.9K
A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
08:35

A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium

Published on: May 18, 2021

7.4K

Area of Science:

  • Environmental Toxicology
  • Hepatology
  • Developmental Biology

Background:

  • Perfluoroundecanoic acid (PFUnA) is a persistent environmental contaminant.
  • Its effects on liver development during puberty remain largely uncharacterized.

Purpose of the Study:

  • To investigate the impact of PFUnA exposure on pubertal liver development in Sprague-Dawley rats.
  • To elucidate the underlying mechanisms, including effects on lipid metabolism, oxidative stress, and inflammation.

Main Methods:

  • Male rats (35 days old) were administered varying doses of PFUnA (1-10 mg/kg/day) for 21 days.
  • Gene and protein expression analysis, inflammatory factor assessment, and in vitro HepG2 cell studies were performed.

Main Results:

  • PFUnA exposure led to increased liver weight and elevated serum alanine aminotransferase.
  • It altered key genes and proteins involved in lipid metabolism (e.g., Lxrα, Hmgcr, Abcg8, Ldlr) and antioxidant defense (e.g., Sod1, Cat).
  • PFUnA induced inflammatory responses and oxidative stress, with similar effects observed in HepG2 cells.

Conclusions:

  • PFUnA exposure during puberty perturbs hepatic lipid metabolism and induces oxidative stress.
  • These disruptions may inhibit normal pubertal liver development.
  • PFUnA poses a potential risk to liver health during critical developmental stages.