Case Report: Carcinoma Ex-Pleomorphic Adenoma With Concurrent Submandibular Gland Lithiasis-A Rare Association With...

Area of Science:

• Otolaryngology
• Surgical Pathology
• Oncology

Background:

• Submandibular gland lithiasis is common, but co-occurrence with malignancy is exceptionally rare.
• Carcinoma ex-pleomorphic adenoma (CXPA) is a rare malignant salivary gland tumor.
• This report details only the fourth documented case of concurrent submandibular gland lithiasis and CXPA.

Purpose of the Study:

• To report an extremely rare case of coexisting submandibular gland lithiasis and CXPA.
• To explore a potential pathophysiological link between chronic inflammation from lithiasis and malignant transformation.
• To emphasize the importance of evaluating chronic submandibular conditions for concurrent malignancy.

Main Methods:

• Case report of a 79-year-old male with a 10-year history of submandibular symptoms.
• Diagnostic evaluation including imaging and post-surgical histopathological analysis.
• 24-month follow-up to assess disease status and functional outcomes.

Main Results:

• The patient presented with both ductal and intraglandular submandibular stones and non-uniform glandular enlargement.
• Histopathological analysis confirmed CXPA.
• The patient remained disease-free with good functional outcomes at 24 months post-surgery.

Conclusions:

• The co-occurrence of submandibular lithiasis and CXPA is exceptionally rare.
• Chronic inflammation associated with long-standing lithiasis may play a role in the malignant transformation to CXPA.
• Comprehensive evaluation of chronic or atypical submandibular gland conditions is crucial to exclude concurrent malignancy.