IgG-Secreting Lymphoplasmacytic Lymphoma Presenting With Massive Kidney Infiltration

Area of Science:

• Nephrology
• Hematology
• Oncology

Background:

• Lymphoplasmacytic lymphoma (LPL) is a rare B-cell malignancy.
• Kidney complications associated with LPL are not well-documented compared to multiple myeloma.
• Tumor infiltration can be a cause of renal dysfunction in lymphoproliferative disorders.

Purpose of the Study:

• To report a case of IgG-secreting LPL presenting with acute kidney injury.
• To highlight direct tumor infiltration as a cause of renal failure in LPL.
• To demonstrate the efficacy of chemotherapy in managing LPL-related kidney disease.

Main Methods:

• Case report detailing clinical presentation, diagnostic workup, and treatment of a patient with LPL.
• Renal biopsy findings confirming direct tumor infiltration by IgG-secreting LPL cells.
• Monitoring of hematological and renal parameters before and after chemotherapy.

Main Results:

• The patient presented with acute kidney injury due to direct infiltration of the kidney by IgG-secreting LPL.
• Renal biopsy confirmed the presence of malignant lymphocytes and plasma cells in the renal parenchyma.
• Chemotherapy led to significant improvements in both hematological and renal function.

Conclusions:

• Direct tumor infiltration by lymphoplasmacytic lymphoma can cause severe acute kidney injury.
• Chemotherapy is an effective treatment modality for LPL-associated renal complications.
• Further research is warranted to better understand and manage kidney involvement in LPL.