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Successful Management of Recurrent Rectal Leiomyosarcoma: A Case Report
Annmarie Butare1, Warqaa Akram1
1Department of Surgery Brody School of Medicine at East Carolina University Greenville North Carolina USA.
Clinical Case Reports
|November 3, 2025
Summary
Rectal leiomyosarcoma, a rare cancer, has a poor prognosis. However, neoadjuvant radiation followed by total mesorectal excision can achieve a disease-free state for patients.
Area of Science:
- Oncology
- Surgical Oncology
- Radiation Oncology
Background:
- Rectal leiomyosarcoma is an uncommon malignancy.
- It is associated with a poor prognosis and high recurrence rates.
- There is no established gold-standard treatment.
Purpose of the Study:
- To investigate the efficacy of neoadjuvant radiation followed by total mesorectal excision for rectal leiomyosarcoma.
Main Methods:
- Neoadjuvant radiation therapy.
- Total mesorectal excision (surgical procedure).
Main Results:
- A disease-free state can be achieved.
- This multimodal approach shows promise in managing rectal leiomyosarcoma.
Conclusions:
- Neoadjuvant radiation and total mesorectal excision represent a viable strategy for rectal leiomyosarcoma.
- This treatment combination offers a pathway to achieving disease-free survival.
