Synovial Sarcoma; a Rare Entity in Submandibular Gland

Salivary gland synovial sarcomas, comprising less than 1% of oral tumors, predominantly manifest in the young and adolescent age group, and pose significant diagnostic challenges. The neoplasm is distinguished by the presence of spindle cells and positivity for CKAE1/AE3, TLE-1, and CD99. CASE SUMMARY: A 48-year-old male patient is presented with a swelling in the left submandibular area, devoid of any other associated symptoms. A thorough excisional histopathological evaluation was conducted, resulting in a diagnosis of unifocal synovial sarcoma. The tumor cells exhibited positivity for CKAE1/AE3, TLE-1, and CD99, while displaying negativity for S100. CONCLUSION: This report contributes to the limited extant regarding this rare malignancy, shedding light on their clinical and diagnostic characteristics.